Causes of von Willebrand Disease
Most people who have VWD are born with it. It almost always is inherited, or passed down, from a parent to a child. VWD can be passed down from either the mother or the father, or both, to the child.
While rare, it is possible for a person to get VWD without a family history of the disease. This happens when a “spontaneous mutation” occurs. That means there has been a change in the person’s gene. Whether the child received the affected gene from a parent or as a result of a mutation, once the child has it, the child can later pass it along to his or her children. Rarely, a person who is not born with VWD can acquire it or have it first occur later in life. This can happen when a person’s own immune system destroys his or her VWF, often as a result of use of a medication or as a result of another disease. If VWD is acquired, meaning it was not inherited from a parent, it cannot be passed along to any children.
Learn more about how VWD is inherited
Source: Centers for Disease Control and Prevention