Results include both upper and lowercase alleles.

Allele Name Nucleotide Exon Amino Acid Linked To Ethnicity & Frequency Antigen Antibody Specificity Clinical Misc Reference Links
RHCE*01 or RHCE*ce
RHCE*c
RHCE*e
Reference nucleotides
307C
676G
2,5 Pro103
Ala226
RH:4 or c, RH:5 or e,RH:6 or f (ce) Mouro et al. 1993
RHCE*01.01
RHCE*ce.01
48G>C 1 Trp16Cys frequently weak e no auto anti~e possible none known Westhoff et al., 2001
RHCE*01.02
RHCE*ce.02
48G>C
1025C>T
1,7 Trp16Cys,Thr342Ile RHCE*ceTI, Almost always linked to RHD*DIVa-2 frequently weak e c and e anti-c,anti-e not known Vege et al., 2007
RHCE*01.03
RHCE*ce.03
1025C>T 7 Thr342Ile linked with DIIIa Westhoff et al., 2010
RHCE*01.04
RHCE*ce.04
48G>C
712A>G
733C>G
787A>G
800T>A 916A>G
1,5,6 Trp16Cys
Met238Val
Leu245Val
Arg263Gly
Met267Lys
Ile306Val
RHCE*ceAR,often linked to RHD*DAR Asian, unknown
Black, ome,none
frequently weak e c and e anti-c,anti-e,anti-RH19 (-hrS),anti-RH18 (-Hr) Transfusion reaction reported,DAT+ to Mild HDFN RH:10, –20 (V+wVS–),RH:–19 (hrS–),RH:–18 (Hr–) Hemker et al., 1999
RHCE*01.05
RHCE*ce.05
48G>C
712A>C
787A>G
800T>A
1,5 Trp16Cys
Met238Val
Arg263Gly
Met267Lys
RHCE*ceEK,often linked to RHD*DAR Asian, unknown
Black, ome,none
Frequently weak e c and e anti-c,anti-e,anti-RH19 (-hrS),anti-RH18 (-Hr) Transfusion reaction reported,DAT+ to Mild HDFN RH:–19 (hrS–),RH:–18 (Hr–) Noizat-Pirenne et al., 2002
RHCE*01.06
RHCE*ce.06
254C>G 2 Ala85Gly RHCE*ceAG Asian, unknown
Black, some, none
weak e e anti-e not known RH:–59 (CEAG–),RH:–31 (hrB–) Vege et al., 2009
RHCE*01.07.01
RHCE*ce.07.01
48G>C
667G>T
1,5 Trp16Cys
Val223Phe
RHCE*ceMO,often linked to RHD*DAU0 Asian, unknown
Black, some, none
weak e c and e anti-c and -e not known RH:–19 (hrS–),RH:–31 (hrB–) Noizat-Pirenne et al., 2001
RHCE*01.07.02 667G>T 5 Val223Phe 2 ARC samples and Flore, Ines at NYBC Asian, unknown
Black, rare
Caucasian, none
RHCE*01.08
RHCE*ce.08
48G>C
712A>G
818C>T
1132C>G
1,5,6,8 Trp16Cys
Met238Val
Ala273Val
Leu378Val
RHCE*ceBI,often linked to RHD*DOL Asian, unknown
Black, ome,unknown
frequently weak e e anti-e,anti-RH19 (-hrS),anti-RH18 (-Hr) not known RH:–19 (hrS–),RH:49 (STEM+) e+/–,RH:–18 (Hr–) Noizat-Pirenne et al., 2002
RHCE*01.09
RHCE*ce.09
48G>C
712A>G
818C>T
1,5,6 Trp16Cys
Met238Val
Ala273Val
ceSM,RHCE*ceSM Asian, unknown
Black, some, unknown
not known not known not known not known RH:–19 (hrS–),Rh:49+w,(STEM+w),e+/– Halter-Hipsky et al., 2009
RHCE*01.10.01
RHCE*ce.10.01
48G>C
365C>T
1,3 Trp16Cys
er122Leu
RHCE*ceSL,Some AlleleNames have a silent 105C>T change Asian, none
Black, none
Caucasian, rare
frequently weak e not known not known Few monoclonal anti-D weakly cross-react (give clones) Chen et al.,2005
RHCE*01.10.02
RHCE*ce.10.02
365C>T 3 Ser122Leu RHCE*ceSL Asian, unknown
Black, unknown
Caucasian, rare
Not known not known not known Few monoclonal anti-D weakly cross-react (give clones) Chen et al.,2005
RHCE*01.11
RHCE*ce.11
461G>C 3 Arg154Thr RHCE*ceRT Asian, rare
Black, unknown
Caucasian, rare
e+w not known not known Some monoclonal anti-D weakly cross-react (reference) Wagner et al.,2003
RHCE*01.12
RHCE*ce.12
48G>C
538G>C
1,4 Trp16Cys
Gly180Arg
RHCE*ceRA Asian, rare
Black, unknown
Caucasian, unknown
e weak +/– not known not known not known Noizat-Pirenne et al., 2006
RHCE*01.13
RHCE*ce.13
685-687
delAGA
5 Arg229del RHCE*ceBP Asian, rare
Black, unknown
Caucasian, unknown
very weak e not known not known not known RH:58 (CELO+w) Chen et al. 2004
RHCE*01.14
RHCE*ce.14
662C>G 5 Pro221Arg RHCE*ceBE Asian, rare
Black, unknown
Caucasian, unknown
weak c,weak e not known not known not known H:36 [Be(a+) Doscher et al.,2009
Hue-Roye et al., 2010
RHCE*01.15
RHCE*ce.15
286G>A 2 Gly96Ser RHCE*ceLOCR Asian, unknown
Black, unknown
Caucasian, rare
weak c not known not known Not known RH:55 (LOCR+),RH:–26 Faas et al., 1997 *b
Coghlan et al., 2006
RHCE*01.20.01
RHCE*ce.20.01
RHCE*ceVS.01
733C>G 5 Leu245Val Often linked to conventional RHD Asian, none
Black, common
Caucasian, none
anti-e (auto)?? Numerous patients have received e+ blood without adverse effects RH:10,20(V+VS+),RH:31 (hrB+w/–) Steers et al., 1996
Huang et al., 1997
Faas et al., 1997 *a
RHCE*01.20.02
RHCE*ce.20.02
RHCE*ceVS.02
48G>C
733C>G
1,5 Trp16Cys
Leu245Val
Often linked to RHD*DIIIa Asian, none
Black, common
Caucasian, none
anti-e (auto)?? Numerous patients have received e+ blood without adverse effects partial e partial c RH:10,20(V+VS+),RH:–31 (hrB–) Faas et al., 1997 *a
RHCE*01.20.03
RHCE*ce.20.03
RHCE*ceVS.03
48G>C
733C>G
1006G>T
1,5,7 Trp16Cys
Leu245Val
Gly336Cys
Often linked to RHD*DIIIa OR hybrid RHDIII-CE-D as part of r’S type 1 or RHD-CE-D type 2 haplotype Asian, none
Black, common
Caucasian, none
e and c anti-e or anti-c not known,When linked with hybrid D-CE-D the C antigen is partial RH:–10,20(V–VS+),RH:–31 (hrB–) Daniels et al., 1998
RHCE*01.20.04
RHCE*ce.20.04
RHCE*ceVS.04
48G>C
733C>G
1025C>T
1,5,7 Trp16Cys
Leu245Val
Thr342Ile
Asian, none
Black, ome,none
not known not known not known partial e,RH:10,20(V+VS+),Probable RH:–31 (hrB–) Westhoff et al., 2010
RHCE*01.20.05
RHCE*ce.20.05
RHCE*ceVS.0
733C>G
1006G>T
5,7 Leu245Val
Gly336Cys
Asian, none
Black, rare
Caucasian, none
not known not known not known partial e RH:–10,20(V–VS+) Daniels et al., 1998
RHCE*01.20.06
RHCE*ce.20.06
RHCE*ceVS.06
48G>C
697C>G
733C>G
1,5 Trp16Cys
Gln233Glu
Leu245Val
RHCE*ceCF Asian, none
Black, some, none
e +/– c and e anti-c,anti-e not known Anti-CELO,DAT+, no HDFN,RH:20 (VS+),RH:43 (Crawford+),RH:–58 (CELO–) Flegel et al., 2006
RHCE*01.20.07
RHCE*ce.20.07
RHCE*ceVS.07
340C>T,733C>G 3,5 Arg114Trp
Leu245Val
RHCE*ceJAL Asian, none
Black, ome,none
e +/–,c +/– c and e anti-e,anti-c anti-c possibly involved in transfusion reaction RH:48,(JAL+),RH:–57(CEST–),RH:20 (V/VS+w),RH:19 (hrS+w/–),RH:31 (hrB+w/–) Noizat-Pirenne et al., 2002
Hustinx et al., 2008
Westhoff et al., 2008
RHCE*01.20.08
RHCE*ce.20.08
RHCE*ceVS.08
48G>C
733C>G
748G>A
1,5 Trp16Cys
Leu245Val
,Val250Met
Asian, none
Black, rare
Caucasian, none
weak e not known not known not known RH:10,20 (V+VS+),Probable RH:–31 (hrB–) Noizat-Pirenne et al., 2002
RHCE*ce.20.09
RHCE*ceVS.09
48G>C
733C>G
941T>C
1006G>T
1,5,7 Trp16Cys
Leu245Val
Val314Ala
Gly336Cys
Asian, none
Black, rare
Caucasian, none
weak e e anti-e not known Hue-Roye et al., 2010
RHCE*01.21
RHCE*ce.21
341G>A 1,2,3 Arg114Gln Asian, one, unknown
Black, one
weak e not known not known not known RH:48 (JAL+) Wagner et al., 2003
Hustinx et al., 2008
RHCE*01.22
RHCE*ce.22
667G>T
697C>G
712A>G
733C>G
744T>C
787A>G
800T>A
5 Val223Phe
Gln233Glu
Mer238Val
Leu245Val
ilent
Arg263Gly
Met267Lys
RHCE*ceHAR Asian, none
Black, none
Caucasian, some
weak e not known not known not known strongly D+ with some monoclonal anti-D,RH:33 (DHAR+),RH:50 (FPPT+) Beckers et al., 1996
RHCE*01.23
RHCE*ce.23
649T>C 5 Trp217Arg Asian, unknown
Black, unknown
Caucasian, rare
Bugert et al., 2009
RHCE*01.24
RHCE*ce.24
512G>A 4 His171Arg Asian, unknown
Black, unknown
Caucasian, rare
weak e** Doscher et al.,2009
RHCE*01.25
RHCE*ce.25
730G>A 5 Ala244Thr Asian, unknown
Black, unknown
Caucasian, rare
weak e** Doscher et al.,2009
RHCE*01.26
RHCE*ce.26
872C>T 6 Pro291Leu Asian, unknown
Black, unknown
Caucasian, rare
weak e** Doscher et al.,2009
RHCE*01.27
RHCE*ce.27
1154G>C 9 Gly385Ala Asian, unknown
Black, unknown
Caucasian, rare
weak e** Doscher et al.,2009
RHCE*01.28
RHCE*ce.28
1254A>C 10 Stop418Tyr Asian, unknown
Black, unknown
Caucasian, rare
weak c** Doscher et al.,2009
RHCE*01.29
RHCE*ceBOL
RHD exon 4-9 9-Apr Reported haplotype,(Dc- Bol) Asian, unknown
Black, unknown
Caucasian, one
C–c+.E–e– Cherif-Zahar et al., 1996
RHCE*01.30
RHCE*ce.30
526G>A 4 Ala176Thr Asian, unknown
Black, rare
Caucasian, unknown
weak e not known not known Pham et al., 2011
RHCE*01.31
RHCE*ce.31
695T>C 5 Ile232Thr Asian, unknown
Black, rare
Caucasian, unknown
weak e Pham et al., 2011
RHCE*01.32
RHCE*ce.32
827C>A 6 Ala276Gln Asian, unknown
Black, rare
Caucasian, unknown
Pham et al., 2011
RHCE*01N.01
,RHCE*ceN.01
80-84 del 1 Lys31Stop Rhnull c–e– anti-Rh17,anti-Rh29 No to severe,No to severe HDFN I entered “anti-Rh29” because these are with a silent/absent RHD Kato-Yamazaki et al., 2000
RHCE*01N.02
RHCE*ceN.02
960-963 delG 7 Gly321fs Rhnull c–e– anti-Rh17,anti-Rh29 Rosa et al., 2005
RHCE*01N.03
RHCE*ceN.03
+1g>t Intron 4 Splice site DAA family,Rhnull c–e– anti-Rh17,anti-Rh29 Cherif-Zahar et al., 1998
RHCE*02 or RHCE*Ce
RHCE*C
RHCE*e
RHCE*Ce
Reference nucleotides
48G>C
178C>A
203A>G
307C>T
1,2 Trp16Cys
Leu60Ile
Asn68Ser
Pro103Ser
Ce,RH:2 or C,RH:5 or e,RH:7 or Ce or rhi Mouro et al., 1993
RHCE*02.01
RHCE*Ce.01
RHCE*CeJAL
340C>T 3 Arg114Trp RHCE*CeMA Asian, unknown
Black, unknown
Caucasian, rare
weak C+ weak e+ not known not known RH:48(JAL+) Noizat-Pirenne et al., 2002
RHCE*02.02
RHCE*Ce.02
667G>T
697C>G
712A>G
5 Val223Phe
Gln233Glu
Met238Val
RHCE*CeVF Asian, unknown
Black, unknown
Caucasian, rare
not known not known Doscher et al., 2004
Bugert et al., 2009
RHCE*02.03
RHCE*Ce.03
365C>T 3 Ser122Leu Asian, unknown
Black, unknown
Caucasian, rare
weak C+,weak e+ not known not known RH:53(JAHK+),rG Scharberg et al., 2005
RHCE*02.04
RHCE*Ce.04
67G>T
697C>G
712A>G
733C>G
744T>C
787A>G
800T>A
RHD ex 5 Val223Phe
Gln233Glu
Mer238Val
Leu245Val
ilent
Arg263Gly
Met267Lys
RHCE*CeVA Asian, unknown
Black, unknown
Caucasian, rare
C weak+/– not known not known partial C Noizat-Pirenne et al., 2002
RHCE*02.08.01
RHCE*Ce.08.01
RHCE*CeCW
122A>G 1 Gln41Arg Asian, unknown
Black, unknown
Caucasian, ome
C,unpublished Anti-C,Anti-rhi not known RH:8 (CW+),RH:–51(MAR–) Mouro et al., 1995
RHCE*02.08.02
RHCE*Ce.08.02
RHCE*CeNR
122A>G
Hybrid RHD exon 6-10
1,6-10 Gln41Arg Asian, unknown
Black, one, unknown
RH:8 (Cw+),RH:–56 (CENR–) Westhoff et al., 2004
RHCE*02.09
RHCE*Ce.09
RHCE*CeCX
106G>A 1 Ala36Thr Asian, unknown
Black, unknown
Caucasian, uncommon
C unpublished Anti-C,Anti-rhi not known RH:9 (CX+),RH –51 (MAR–) Mouro et al., 1995
RHCE*02.10.01
RHCE*Ce.10.01
RHCE*CeRN.01
505C>A
509G>T
514T>A
544A>T
577A>G
594T>A
602G>A
4 Leu169Met
Arg170Met
Phe172Ile
Thr182Ser
Lys193Glu
Asn198Lys
Arg201Thr
Asian, one, some, none weak C+,weak e+ C Anti-C,Anti-Rh46 Anti-Rh46 and anti-C are Clinically significant.,No to severe HDFN,RH:32 (RN),RH:54 (DAK+),RH:–46 (Sec–) Rouillac et al., 1996
RHCE*02.10.02
RHCE*Ce.10.02
RHCE*CeRN.02
455C>A
505C>A
509G>T
514T>A
544A>T
577A>G
594T>A
602G>A
3,4 Thr152Asn
Leu169Met
Arg170Met
Phe172Ile
Thr182Ser
Lys193Glu
Asn198Lys
Arg201Thr
Asian, none
Black, some, none
weak C+, weak e+ C Anti-C,Anti-Rh46 Anti-Rh46 and anti-C are Clinicalally significant.,No to severe HDFN RH:32 (RN),RH:54 (DAK+),RH:–46 (Sec–) Rouillac et al., 1996
RHCE*02.11
RHCE*Ce.11
286G>A 2 Gly96Thr Asian, unknown
Black, unknown
Caucasian, rare
weak C** Doscher et al.,2009
RHCE*02.12
RHCE*Ce.12
344T>G 3 Leu155Arg Asian, unknown
Black, unknown
Caucasian, rare
weak C** Doscher et al.,2009
RHCE*02.13
RHCE*Ce.13
364T>C 3 Ser122Pro Asian, unknown
Black, unknown
Caucasian, rare
e+w Bugert et al., 2009
RHCE*02.14
RHCE*Ce.14
497A>T 4 His166Leu Asian, unknown
Black, unknown
Caucasian, rare
weak C** Bugert et al., 2009
RHCE*02.15
RHCE*Ce.15
689G>C 5 Ser230Thr Asian, unknown
Black, unknown
Caucasian, rare
weak e** Doscher et al.,2009
RHCE*02.16
RHCE*Ce.16
728A>G 5 Tyr243Cys Asian, unknown
Black, unknown
Caucasian, rare
weak C,weak e** Douscher et al.,2009
RHCE*02.17
RHCE*Ce.17
800T>A 5 Met267Lys Asian, unknown
Black, unknown
Caucasian, rare
e+w Bugert et al., 2009
RHCE*02.18
RHCE*Ce.18
890T>C 6 Leu297Pro Asian, unknown
Black, unknown
Caucasian, rare
weak C,weak e+** Doscher et al.,2009
RHCE*02.19
RHCE*Ce.19
464T>G
1118C>T
3,8 Met155Arg
Ala373Val
Asian, unknown
Black, unknown
Caucasian, rare
weak e** Doscher et al.,2009
RHCE*02.20
RHCE*Ce.20
79-81 delCTC 1 Leu27del Asian, unknown
Black, unknown
Caucasian, rare
weak C** e+w Doscher et al.,2009
RHCE*02.21
RHCE*Ce.21
527C>T 4 Ala176Val Asian, unknown
Black, unknown
Caucasian, rare
weak C Pham et al., 2011
RHCE*02.22
RHCE*Ce.22
667G>T 5 Val223Phe Asian, unknown
Black, unknown
Caucasian, rare
weak C,weak e Pham et al., 2011
RHCE*02.23
RHCE*Ce.23
941T>C 7 Val314Ala Asian, unknown
Black, unknown
Caucasian, rare
weak C Pham et al., 2011
RHCE*02.24
RHCE*Ce.24
1007G>A 7 Lys336Asp Asian, unknown
Black, unknown
Caucasian, rare
weak C,weak e Pham et al., 2011
RHCE*02.25
RHCE*Ce.25
1007G>T 7 Lys336Val Asian, unknown
Black, unknown
Caucasian, rare
weak C Pham et al., 2011
RHCE*02N.01
RHCE*CeN.01
966-969 del 7 His323 fs
Gly398Stop
C–e– Anti-Rh17? Cherif-Zahar et al., 1998
Huang et al., 1998
RHCE*03 or RHCE*cE
RHCE*c
RHCE*4
RHCE*E
RHCE*3
Reference
676G>C
5 Ala226Pro 6 cE,RH:4 or c,RH:5 or e,RH:27 Mouro et al., 1993
RHCE*03.01
RHCE*cE.01
500T>A 5 Met167Lys RHCE*cEEW Asian, rare
Black, unknown
Caucasian, rare
E weak+/– E Anti-E RH:11 (EW +),E type I Noizat-Pirenne et al., 1998
Strobel et al., 2004
RHCE*03.02
RHCE*cE.02
hybrid, D/CE(1) D(2, 3) CE(4-10) RHD exon 1-3 RHCE*cEKK Asian, rare
Black, unknown
Caucasian, rare
E,weak+/–,c weak+/– E type II Noizat-Pirenne et al., 1998
Kashiwase et al., 2001
RHCE*03.03
RHCE*cE.03
697C>G
712A>G
5 Gln233Glu
Met238Val
RHCE*cEFM Asian, rare
Black, unknown
Caucasian, rare
E weak +/– no E type III Noizat-Pirenne et al., 1998
RHCE*03.04
RHCE*cE.04
602G>C 4 Arg201Thr Asian, unknown
Black, unknown
Caucasian, rare
E weak +/– no E type IV Noizat-Pirenne et al., 1999
RHCE*03.05
RHCE*cE.05
461G>C 3 Arg154Thr RHCE*cEKH Asian, rare
Black, unknown
Caucasian, unknown
E weak +/–,c weak +/– E Anti-E c+w,E type V Kashiwase et al., 2001
RHCE*03.06
RHCE*cE.06
28C>T 1 Arg10Trp Asian, unknown
Black, unknown
Caucasian, rare
weak c**,weak E Bugert et al., 2009
RHCE*03.07
RHCE*cE.07
344T>C 3 Leu115Pro Asian, unknown
Black, unknown
Caucasian, rare
weak E+** Doscher et al.,2009
Bugert et al., 2009
RHCE*03.08
RHCE*cE.08
356G>A 3 Ser119Asn weak E+** Doscher et al.,2009
RHCE*03.09
RHCE*cE.09
374T>A 3 Ile125Asn Asian, unknown
Black, unknown
Caucasian, rare
weak c**,weak E** Bugert et al., 2009
RHCE*03.10
RHCE*cE.10
506T>A 4 Ile169Gln Asian, unknown
Black, unknown
Caucasian, rare
weak E** Bugert et al., 2009
RHCE*03.11
RHCE*cE.11
908T>A 6 Leu303Gln Asian, unknown
Black, unknown
Caucasian, rare
weak c**,weak E Bugert et al., 2009
RHCE*03.12
RHCE*cE.12
464T>G
477T>G
3 Met155Arg
Asn159Lys
Asian, unknown
Black, unknown
Caucasian, rare
weak E+** Doscher et al.,2009
RHCE*03.13
RHCE*cE.13
728A>G 5 Tyr243Cys Asian, unknown
Black, unknown
Caucasian, rare
weak E,weak c Pham et al., 2011
RHCE*03.14
RHCE*cE.14
734T>C 5 Leu245Pro Asian, unknown
Black, unknown
Caucasian, rare
E very weak+/–,weak c Silvy et al.,2010
RHCE*03.15.01
RHCE*cE.15.01
380C>T
383G>A
3 Ala127Val
Gly128Asp
cE BA Asian, unknown
Black, unknown
Caucasian, rare
weak E Pham et al., 2011
RHCE*03.15.02
RHCE*cE.15.02
361A>T
380C>T
383G>A
3 Met121Leu
Ala127Val
Gly128Asp
Asian, unknown
Black, unknown
Caucasian, rare
weak E cE JU Pham et al., 2011
RHCE*03N.01
RHCE*cEN.01
350-358del 3 Deletion of Arg120-Ser122 RHCE*cEMI Asian, unknown
Black, unknown
Caucasian, one
c–E– Anti-Rh17? Noizat-Pirenne et al., 2001
RHCE*03N.02
RHCE*cEN.02
907delC 6 Leu303Stop Asian, unknown
Black, unknown
Hispanic, some
Caucasian, unknown
c–E– Westhoff et al., 2011
RHCE*CE or RHCE04
RHCE*C
RHCE*2
RHCE*E
RHCE*3
Reference
48G>C
150C>T
178C>A
201A>G
203A>G
307C>T
676G>C
1,2,5 Trp16Cys
Leu60Ile
Asn68Ser
Pro103Ser
Ala226Pro
CE,RH:2 or C,RH:3 or E,RH:22 C typing may be weaker than expected and/or mixed field may be observed Mouro et al., 1993
RHCE*04.01
RHCE*CE.01
722C>T 5 Thr241Ile Asian, unknown
Black, unknown
Caucasian, one
Weak C,E weak+/– Bugert et al., 2009